Cefpodoxime: Uses, Side effects, Dosage, Interactions, Contraindications

Overview: 

Cefpodoxime is a third generation cephalosoprine. It is used to treat mild to moderate bacterial infections. It is effective against both gram positive and gram negative organisms.

☞ If you are allergic to other cephalosoprines or penicillins than avoid Cefpodoxime.

Bioavailability: 50%
Plasma protein binding: 18 to 25%
Route: Oral
Trade name: Vantin
Plasma half life: 2 hours

Mechanism of Action: 

Cephalosoprines inhibit bacterial cell wall synthesis in a manner similar to penicillins.

 Uses: 

Cefpodoxime is used orally to treat a broad range of bacterial infections (except Pseudomonas aeruginosa, Bacteroides fragilis, Enteroccocus). It is used to treat -
  • Bronchitis
  • Tonsillitis
  • Sinusitis
  • Cystitis
  • Otitis media
  • Skin or soft tissue Infections
  • Gonococcal infections
  • Upper respiratory tract infections

Dosage

1. Bronchitis
  • Adult dose: 200 mg q12h for 10 days
  • Pediatric dose: ≥12 years 200 mg q12h for 10 days
2. Tonsillitis/pharyngitis
  • Adult dose: 100 mg q12 h for 5-10 days
  • Pediatric dose: <12 years age, 5 mg/kg/dose (max 100 mg) q12h for 5 to 10 days, for >12 years 100 mg q12h for 5 to 10 days.
3. Sinusitis
  • Adult dose: 200 mg q12h for 5 to 10 days
  • Pediatric dose: <12 years 5 mg/kg/dose (max 200 mg) q12h for 5 to 10 days, >12 years 200 mg q12h for 10 days
4. Cystitis
  • Adult dose: 100 mg q12h for 7 days
  • Pediatric dose: ≥12 years 100 mg q12h for 7 days
5. Otitis media
  • Pediatric dose: 5 mg/kg/dose q12h for 5 days
6. Gonococcal infection uncomplicated
  • Adult dose: 200 mg once (female anorectal infections)
  • Pediatric dose: ≥12 years 200 mg once (female anorectal infections)
7. Skin amd soft tissue infections
  • Adult dose: 400 mg q12h for 12 hours 7-10 days
  • Pediatric dose: ≥12 years 400 mg q12h 7-10 days
8. Respiratory tract infections:
  • Adult dose: 100 mg q12h for 10-days

Side Effects: 

Side effects that you should report your doctor or physician-
  • Diarrhea (Clostridium difficile)
  • Allergic reactions like skin rashes, itching
  • change in vaginal discharge color, odor
  • Difficulty in breathing
  • Confusion, nervousness
  • Burning sensation during urination
Side effects that can be ignored or not require any medical attention-
  • Vomiting
  • Headache
  • Fever
  • Abdominal pain
  • Dry mouth
For more details of side effects and their severity consult your doctor or pharmacist.

Interactions: 

Cefpodoxime may alter the plasma concentration and toxicity of other drugs
  • Diuretics like furosemide, chlorthalidone
  • Antacids
  • Probenecid

Contraindications: 

Cefpodoxime is contradictory for patients who are allergic to this or other cephalosoprines and penicillins.

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