Ofloxacin: Uses, Dosage, Side Effects, Contraindications

Overview: 

Ofloxacin is a first generation fluoroquinolone. It is used to treat a certain variety of mild to moderate bacterial infections. It does not work against virus Infections (common cold and flu).

Warning- 

This medication sometimes may cause tendon damage (tendonitis or tendon rupture). If you are above 60 years or taking steroid therapy and if you have lung, kidney, heart transplant, chances of tendon damage are high.
  • Oral bioavailability: 85-95%
  • Plasma protein binding: 25%
  • Plasma half life: 5-8 hours
  • Routes of administration: Oral, IV
  • Dosage: Oral 200-400, IV 200
  • Trade name: Floxin, ocuflox, zenocin, tarivid, zenflox

Mechanism of action

Ofloxacin inhibits the enzyme bacterial DNA gyrase in gram negative bacteria and topoisomerase-4 in gram positive bacteria, thus interfering with the DNA separation which creates difficulty in cell division in bacteria.

Uses

It is used to treat following bacterial infections-
  1. Acute bacterial exacerbations of chronic bronchitis
  2. Community acquired pneumonia
  3. Uncomplicated skin infections
  4. Nongonococcal urethritis and cervicitis
  5. Acute pelvic inflammatory disease
  6. Uncomplicated and complicated urinary tract infections
  7. Used against M. Leaprae as alternative multidrug therapy regimen.
  8. ENT infections
  9. Infectious diarrhea

Dosage

  1. Acute bacterial exacerbation of chronic bronchitis: 400 mg q12h for 10 days.
  2. Community acquired pneumonia : 400 mg q12h for 10 days
  3. Uncomplicated skin and skin structure infections: 400 mg q12h for 10 days
  4. Acute pelvic inflammatory disease:  400 mg q12h for 10-14 days
  5. Complicated urinary tract infections:  200 mg q12 h for 10 days
  6. Prostatitis: 300 mg q12h for 6 weeks
  7. acute uncomplicated urethral and cervical gonorrhea: 400 mg single dose for 1 day

Side effects

If any of the following side effects occur consult your doctor-
  • Confusion
  • Depression
  • Diarrhea
  • Hallucinations
  • Irregular heartbeat
  • Joint, muscles or tendon pain swelling
  • Tingling and numbness in the hands and feet
  • Change in mood or suicidal thought
  • Skin rashes
  • Tiredness
  • Nausea, vomiting, diarrhea, abdominal pain, gas, loss of appetite
  • Headache, dizziness
  • Dry mouth
  • Insomnia
  • Tremors, seizures
  • Anxiety

Interactions

drugs that may interact with ofloxacin are-
  • NSAIDs
  • Amiodarone
  • Amantadine
  • Alfuzosin
  • Antihistamines
  • antipsychotics
  • Apomorphine
  • Chloroquine
  • Cimetidine
  • Corticosteroids
  • Cyclosporine
  • Decarbazine
  • Domperidone
  • Duloxetine
  • Diabetes drugs like glipizide, insulin, metformin
  • Famotidine
  • Formoterol
  • Galantamine
  • Indapamide
  • Iron supplements
  • Lithium
  • Pentamidine
  • Pimozide
  • Porfimer
  • Probenecid
  • Warfarin
  • Theophylline

Consult your doctor if you are taking above medicines before starting ofloxacin, he can guide you about all interactions related to this drug.

Contraindications

  • If you are hypersensitive to ofloxacin stop taking medicine and consult your doctor.
  • After starting ofloxacin therapy if you feel any pain in muscles or joints stop taking this drug.

NOTE- consult doctor or phramacist for complete detail and guide about this drug.

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